Regional technology investment and output capacity is the key to regional independent innovation. Technology investment and output capacity depends on the investment of funds, the investment of science and technology human capital, the efficiency of input and output of science and technology funds. Through the comparative analysis of these three kinds of indicators and the analysis of multivariate clustering, it is found that the technological input And the output capacity of non-balanced characteristics, and with the developed provinces and cities there is a gap; to upgrade the northeast old industrial base of science and technology investment and output capacity is the key to play a regional science and technology innovation integration effect, build a diversified scientific and technological innovation investment and financing system, Innovation environment and incentive mechanism.